Changes

(Equine SCID)

(Equine SCID)

*Autosomal recessive

 

*Occurs in 2-3% of Arabian foals

 

Severe combined immunodeficiency disease (SCID) of horses is an autosomal, recessive hereditary disease occurring in 2-3% of Arab or cross-bred Arab foals. It is characterised by a complete absence of functional B and T lymphocytes and affected (homozygous) foals fail to produce antigen-specific immune responses.

 

*Defect in DNA-dependent protein kinase gene

*Defect in DNA-dependent protein kinase gene

**Gene codes for a DNA repair enzyme involved in V(D)J recombination for antigen receptors of [[Lymphocytes - Introduction|lymphocytes]] (e.g. Ig and TCR)

**Gene codes for a DNA repair enzyme involved in V(D)J recombination for antigen receptors of [[Lymphocytes - Introduction|lymphocytes]] (e.g. Ig and TCR)