Changes

BVDV can be transmitted from infected to susceptible cattle in several ways. Firstly, direct contact with an animal shedding BVDV in its secretions and excretions can cause disease. Virus is shed by both acutely and persistently infected (PI) animals but levels of shedding are much higher in persistently infected cattle, which are a natural reservoir for virus. It is estimated that the incidence of persistently infected animals may be as high as 1-2% of cattle less than one year of age. On a farm, PI cattle are often found in cohorts of similarly aged animals. This is because persistent infections arise when pregnant animals are acutely infected, and so an outbreak of acute, possibly subclinical, BVD in pregnant cattle can later result in a "batch" of PI calves.

BVDV can be transmitted from infected to susceptible cattle in several ways. Firstly, direct contact with an animal shedding BVDV in its secretions and excretions can cause disease. Virus is shed by both acutely and persistently infected (PI) animals but levels of shedding are much higher in persistently infected cattle, which are a natural reservoir for virus. It is estimated that the incidence of persistently infected animals may be as high as 1-2% of cattle less than one year of age. On a farm, PI cattle are often found in cohorts of similarly aged animals. This is because persistent infections arise when pregnant animals are acutely infected, and so an outbreak of acute, possibly subclinical, BVD in pregnant cattle can later result in a "batch" of PI calves.

Transmission to heifers and cows may also occur venereally or via artificial insemination as acutely and persistently unfected bulls sheed bovine viral diarrhoea virus in their semen²⁴. The testes is an immunoprivileged site, and the virus can persist in this location despite otherwise systemic clearance²⁵. Indirect spread is possible: BVDV has been shown to spread through the re-use of needles, nose tongs²⁶ and rectal gloves²⁷, and blood feeding flies also give transmission.

Transmission to heifers and cows may also occur venereally or via artificial insemination as acutely and persistently unfected bulls shed bovine viral diarrhoea virus in their semen²⁴. The testes is an immunoprivileged site, and the virus can persist in this location despite otherwise systemic clearance²⁵. Indirect spread is possible: BVDV has been shown to spread through the re-use of needles, nose tongs²⁶ and rectal gloves²⁷, and blood feeding flies also give transmission.

==Pathogenesis==

==Pathogenesis==