patients with abnormalities of either primary or secondary haemostasis may show external haemorrhage such as epistxis, haematemesis, melaena and haematuria.. Sever blood loss may cause hypovolaemia and/or anaemia. Small volumes of blood within a sensitive location (for example, the brain, eyes. spinal cord or pericardial sac) can cause dramatic clinical signs. Many patients with haemostatic defects, however, can appear to be stable or clinically normal. | patients with abnormalities of either primary or secondary haemostasis may show external haemorrhage such as epistxis, haematemesis, melaena and haematuria.. Sever blood loss may cause hypovolaemia and/or anaemia. Small volumes of blood within a sensitive location (for example, the brain, eyes. spinal cord or pericardial sac) can cause dramatic clinical signs. Many patients with haemostatic defects, however, can appear to be stable or clinically normal. |