Changes

==Pathogenesis==

==Pathogenesis==

SCID occurs due to a mutation in the allele encoding for DNA-dependent protein kinase (DNA-PK) that is involved in V(D)J lymphocyte recombination. V(D)J recombination is required for antigenic receptor expression on B and T lymphocytes. Without these receptors, differentiation of B and T lymphocytes does not occur and lymphoid tissue fails to develop. The result of this mutation is a complete is a severe immunodeficiency.  

SCID occurs due to a mutation in the allele encoding for DNA-dependent protein kinase (DNA-PK) that is involved in V(D)J lymphocyte recombination. V(D)J recombination is required for antigenic receptor expression on B and T lymphocytes. Without these receptors, differentiation of B and T lymphocytes does not occur and lymphoid tissue fails to develop. The result of this mutation is a severe immunodeficiency.  

==Clinical signs==

==Clinical signs==

==Treatment==

==Treatment==

Medical treatment of foals with SCID is generally unrewarding. Treatment is supportive, consisting of antiobiotics to treat secondary infections.  

Medical treatment of foals with SCID is generally unrewarding. Treatment is supportive, consisting of antibiotics to treat secondary opportunistic infections.  

==Prognosis==

==Prognosis==