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→Fibrin Degradation Products
===Fibrin Degradation Products===
===Fibrin Degradation Products===
A latex agglutination test is available for fibrin degradation products (FDP). To perform the test, anti-FDP antibodies adsorbed onto latex particles are added to serial dilutions of test serum. If agglutination is seen at a particular dilution, the test is positive. The most dilute sample that agglutinates gives the overall result of the test. Normal values are between 1/4 and 1/16.
A latex agglutination test is available for fibrin degradation products (FDP). To perform the test, anti-FDP antibodies attached to latex particles are added to serial dilutions of test serum. If agglutination is seen at a particular dilution, the test is positive. The most dilute sample that agglutinates gives the overall result of the test. Normal values are between 1/4 and 1/16.
Although the test is simple to perform, interpretation may be challenging. This is because other small fragments involved in the homeostasis of fibrinogen and fibrin are measured by the test in addition to ''bona fide'' firbrin degradation products. In general though, an increase in FDP correspons to increased fibrinolysis. This can be due to a local problem of fibrin generation such as thrombosis, trauma or chronic bleeding, or be related to a systemic process, usually DIC<sup>3</sup>.
Although the test is simple to perform, interpretation may be challenging. This is because other small fragments involved in the homeostasis of fibrinogen and fibrin are measured by the test in addition to ''bona fide'' fibrin degradation products. In general, an increase in FDP correspons to increased fibrinolysis. This can be due to a local problem of fibrin generation such as thrombosis, trauma or chronic bleeding, or be related to a systemic process, usually DIC<sup>3</sup>.
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