Changes

==Description==

==Description==

Atopic dermatitis is a heritable disorder in which animals are hypersenstive to common environmental allergens, such as pollens, moulds and house dust mites. It is one of the most common skin diseases of dogs worldwide.

Atopic dermatitis is a heritable disorder in which animals are hypersenstive to common environmental allergens. It is one of the most common skin diseases of dogs worldwide.

susceptible animals become sensitiesd to environmental allergens by producing allergen-specific IgE, which binds to receptor sites on cutaneous mast cells. Gurther allergen exposure (probably by percutaneous absoprtion) causes mat cell degranulation, which is a type 1 immediate hypersensitivity reaction, and results in the release of histamine, cytokines, chemokines, and many other chemical mediators. A Th2-type cytokine response predominates. bacterial superantigens, autoantigens release via keratinocyte samage plays a role in perpetuating inflammation.

Susceptible produce allergen-specific IgE to normally-innocuous environmental allergens. This IgE then binds to receptors on cutaneous mast cells to facilitate degranulation on further allergen exposure¹. It is thought that allergen exposure occures via percutaneous absoprtion. Degranulation of mast cells in response to allergen-specific IgE is a type 1 (immediate) hypersensitivity reaction, which results in the release of histamine, cytokines, chemokines, and other chemical mediators. The cytokines involved are biased towards a Th2-type response, with particularly high production of IL-4. IL-4 is a key cytokine for further production of IgE by B-cells. . bacterial superantigens, autoantigens release via keratinocyte samage plays a role in perpetuating inflammation.

==Signalment==

==Signalment==