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In most cases, anti-inflammatory drugs are required in addition to topical treatments and allergen-specific therapy to control residual pruritus and inflammation. The dose and treatment regime should be adapted according to how successful other treatments are, the response to treatment and the presence of allergen in the environment (for example, pollen is present in the summer but not the winter). The aim should be to use the minimum dose that gives effective control of pruritus.
In most cases, anti-inflammatory drugs are required in addition to topical treatments and allergen-specific therapy to control residual pruritus and inflammation. The dose and treatment regime should be adapted according to how successful other treatments are, the response to treatment and the presence of allergen in the environment (for example, pollen is present in the summer but not the winter). The aim should be to use the minimum dose that gives effective control of pruritus.
Cyclosporine is an immunosuppressive drug that acts by suppressing T-cells, as well as mast cells and eosinophils. The doses used in atopy are immuno-modulating, and suppression of these cells impairs antigen presentation, IgE production and the development of inflammatory lesions.<sup>4</sup>. Studies have suggested that cyclosporine is at least as effective as prednisolone for controllin atopic dermatitis<sup>4</sup>, but is better tolerated than the corticosteroid.
eosinophils. This has profound effects on antigen
presentation, IgE production, mononuclear cell
lesions, although at the doses used in canine AD,
Cyclosporine is well tolerated by the majority of dogs.
Cyclosporine is well tolerated by the majority of dogs.
weeks either side of vaccination, although this
weeks either side of vaccination, although this
will lead to worsening of the skin condition.
will lead to worsening of the skin condition.
Cyclosporine is administered for canine AD at a
dose of 5 mg/kg once daily. Glucocorticoids can be initially coadministered
to achieve more rapid remission.
Approximately one third of treated dogs require
daily dosing, one third every other day and one
third twice weekly to maintain remission.
Using cyclosporine as part of an integrated
management program can be more cost-effective
than relying on it alone.
The effect on intradermal testing and serology is
thought to be minimal, although the data is sparse.
Anecdotal data suggests that cyclosporine does
not affect the response to ASIT any more than
glucocorticoids
====Phytopica™====
====Phytopica™====