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| | ====Hydrocortisone aceponate==== | | ====Hydrocortisone aceponate==== |
| − | Hydrocortisone aceponate is a novel topical | + | Hydrocortisone aceponate is a topical glucocorticoid that relieves pruritus. The topical administration and the fact that hydrocotisone aceponate is metabolised in the dermis means that many of the traditional side-effects of glucocorticoid therapy are avoided<sup>4</sup>. The product is potent, and rapidly exerts its effects following application. |
| − | diester glucocorticoid for the treatment of pruritus
| + | |
| − | in dogs. Topical diester glucocorticoids overcome
| + | Early studies (unpublished) demonstrated good |
| − | many of the adverse effects traditionally
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| − | associated with systemic or topical glucocorticoid
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| − | therapy. They are rapidly absorbed and exert
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| − | potent anti-inflammatory effects within the
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| − | epidermis and superficial dermis. Metabolism
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| − | within the dermis, however, ensures that very
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| − | little active compound reaches deeper tissues
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| − | and the circulation, minimizing skin thinning
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| − | and systemic effects. The topical formulation,
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| − | furthermore, eases topical administration. The
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| − | small dose volume, very small droplet size and
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| − | volatile carrier help to ensure quick and easy
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| − | application, penetration of even haired skin and | |
| − | rapid drying with minimal cutaneous after
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| − | effects. The spray is formulated such that two
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| − | sprays from 10 cm away will penetrate the coat
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| − | and treat a 10 x 10 cm (i.e. palm sized area of
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| − | skin). Early studies (unpublished) demonstrated good
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| | efficacy and safety in short term treatment of | | efficacy and safety in short term treatment of |
| | various pruritic disorders in dogs including | | various pruritic disorders in dogs including |