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Feline Immunodeficiency Virus (view source)
Revision as of 10:59, 27 August 2010
, 10:59, 27 August 2010no edit summary
{{unfinshed}}
==Description==
==Agent==
==Transmission and Epidemiology==
Feline Immunodeficiency Virus is commonly abbreviated to FIV
Feline Immunodeficiency Virus is commonly abbreviated to FIV
*Unrelated to HIV
*Unrelated to HIV
*No vaccinal protection between USA Petulama prototype and UK (Hayling Island) isolate
*No vaccinal protection between USA Petulama prototype and UK (Hayling Island) isolate
*Cats, including large cats on game reserves
*Cats, including large cats on game reserves
*Transfer via '''saliva''', though usually through a '''bite''' (FIV is the '''disease of enemies''')
*Can transfer via '''milk''' or '''mutual grooming''' in multicat households
*Also transferred via '''mating'''
*Particular concern amongst '''stray males''': 3.5% of healthy UK cats are seropositive, but in stray toms, up to 10% are positive
*Four-fold more common in diseased cats than in healthy cats
==Pathogenesis==
*Receptor: CD134, found on monocyte-derived macrophages and activated T cells
*Receptor: CD134, found on monocyte-derived macrophages and activated T cells
**Net effect: disruption of acquired immune response
**Net effect: disruption of acquired immune response
**#*Virus-ridden T cell destroy normal T cells, causing chronic immunosuppression
**#*Virus-ridden T cell destroy normal T cells, causing chronic immunosuppression
====Diagnosis====
==Diagnosis==
===Clinical Signs===
===Laboratory Tests===
*'''ELISA''' for serum '''antibody'''
*'''ELISA''' for serum '''antibody'''
**False positives occur, particularly in the presence of maternal Ab
**False positives occur, particularly in the presence of maternal Ab
*Positives can be confirmed by lab work (Western blotting)
*Positives can be confirmed by lab work (Western blotting)
====Control====
===Pathology===
==Control==
*'''No UK vaccine'''
*'''No UK vaccine'''
*Healthy positive cats should have diagnose confirmed by further testing
*Healthy positive cats should have diagnose confirmed by further testing