Line 26: |
Line 26: |
| '''Melanosis''' occurs in several organs, including the anteroventral meninges of the olfactory bulbs, optic nerves, parathyroid glands, heart valves, and spleens of melanotic mouse strains, such as B6 mice. | | '''Melanosis''' occurs in several organs, including the anteroventral meninges of the olfactory bulbs, optic nerves, parathyroid glands, heart valves, and spleens of melanotic mouse strains, such as B6 mice. |
| | | |
− | ==[[Laboratory mice strain information|Strain Information]]== | + | ==Strain Information== |
| Most laboratory mice have contributions from both Mus musculus musculus and Mus musculus domesticus. There is evidence that smaller contributions also may have come from Mus musculus molossinus and Mus musculus castaneus. Therefore, they should not be referred to by species name, but rather as laboratory mice or by use of a specific strain or stock name. (In addition, some recently developed laboratory mouse strains are derived wholly from other Mus species or other subspecies, such as M. spretus). The laboratory mouse genome, including its retroelements, is a mosaic and an artificial creation, and there is no true "wildtype" laboratory mouse. | | Most laboratory mice have contributions from both Mus musculus musculus and Mus musculus domesticus. There is evidence that smaller contributions also may have come from Mus musculus molossinus and Mus musculus castaneus. Therefore, they should not be referred to by species name, but rather as laboratory mice or by use of a specific strain or stock name. (In addition, some recently developed laboratory mouse strains are derived wholly from other Mus species or other subspecies, such as M. spretus). The laboratory mouse genome, including its retroelements, is a mosaic and an artificial creation, and there is no true "wildtype" laboratory mouse. |
| There are over 450 inbred strains that have arisen during the last century but the great majority of biomedical resaerch, including genomic research, is based on a relatively few mouse strains, including C57BL/6, BALB/c, C3H/He, 129, FVB, and outbred Swiss stocks. | | There are over 450 inbred strains that have arisen during the last century but the great majority of biomedical resaerch, including genomic research, is based on a relatively few mouse strains, including C57BL/6, BALB/c, C3H/He, 129, FVB, and outbred Swiss stocks. |
| + | |
| + | '''For more information on specific strains and the pathology associated with them, click [[Laboratory mice strain information|here]] |
| | | |
| ==[[Genetically Engineered Mice]]== | | ==[[Genetically Engineered Mice]]== |