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Canine Cyclic Haematopoiesis (view source)
Revision as of 22:30, 31 August 2010
, 22:30, 31 August 2010→Diagnosis
[[Image:Grey Collie Syndrome.jpg|thumb|Appearance of a puppy with Grey Collie syndrome<br><small>Copyright Michelle Tennis & Peggy Melton]]</small>
[[Image:Grey Collie Syndrome.jpg|thumb|Appearance of a puppy with Grey Collie syndrome<br><small>Copyright Michelle Tennis & Peggy Melton]]</small>
Affected animals have a '''diluted grey coat colour''' and are often '''smaller than their littermates'''. The majority of other clinical signs relate to the reductions in various types of cell, including:
Affected animals have a '''diluted grey coat colour''' and are often '''smaller than their littermates'''. The majority of other clinical signs relate to the reductions in various types of cell, including:
*'''Pyrexic''', '''lethargy''' and '''depression''' due to infection which develops rapidly in neutropenic animals.
*'''Pyrexia''', '''lethargy''' and '''depression''' due to infection which develops rapidly in neutropenic animals.
*Signs of specific infections, including dyspnoea, diarrhoea, oral, nasal and ocular discharge, joint pain and generalised lymph node enlargement.
*Signs of specific infections, including dyspnoea, diarrhoea, oral, nasal and ocular discharge, joint pain and generalised lymph node enlargement.
Most affected animals die within a few weeks of birth and rarely survive to 2-3 years.
Most affected animals die within a few weeks of birth and rarely survive to 2-3 years.
===Other Tests===
===Other Tests===
'''Bone marrow aspirates''' can be used to demonstrate alterations in the erythroid: myeloid ratio, changes that precede the fluctuations in blood cell levels.
'''Bone marrow aspirates''' can be used to demonstrate alterations in the erythroid: myeloid ratio, changes that generally precede the fluctuations in blood cell levels.
'''Genetic tests''' are available to detect the genetic mutation. These tests can be used to detect heterozygous carriers and to prevent them from breeding.
'''Genetic tests''' are available to detect the mutation. These tests can be used to detect heterozygous carriers and to prevent them from breeding.
==Treatment==
==Treatment==