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Leptospirosis can be caused by infection with a number of different serovars of the bacteria Leptospira interrogans. In general infection with a host adapted strain results in subclinical infection, intermittent shedding of the organism and the animal acts as a reservoir for infection. Infection with non host adapted strains results in clinical disease.  
 
Leptospirosis can be caused by infection with a number of different serovars of the bacteria Leptospira interrogans. In general infection with a host adapted strain results in subclinical infection, intermittent shedding of the organism and the animal acts as a reservoir for infection. Infection with non host adapted strains results in clinical disease.  
 
    
 
    
***Serovars ''canicola'' and ''icterohaemorrhagica'' cause leptospirosis in dogs, but are vaccinated against
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Vaccination against serovars ''canicola'' and ''icterohaemorrhagica'' has greatly reduced the prevalence and incidence of disease in the UK
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***Serovars ''pomona'' and ''grippotyphosa'' are becoming important
 
***Serovars ''pomona'' and ''grippotyphosa'' are becoming important
 
***The host-adapted serovar ''canicolar'' causes acute renal failure in puppies; a chronic uraemic syndrome may follow
 
***The host-adapted serovar ''canicolar'' causes acute renal failure in puppies; a chronic uraemic syndrome may follow
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==Signalment==
 
==Signalment==
 
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Leptospirosis can affect dogs of any age, breed or sex. Young male, adult working dogs are at greatest risk.
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==Diagnosis==
 
==Diagnosis==
 
===Clinical Signs===
 
===Clinical Signs===
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