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==Humoral==
 
==Humoral==
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*[[Complement|Complement]] activation of the classical pathway
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Humoral immunity includes [[Complement|Complement]] activation of the classical pathway. It results in the production of [[Immunoglobulin M|IgM]] and [[Immunoglobulin G|IgG]] and makes the complement system more efficient.
**Production of [[Immunoglobulin M|IgM]] and [[Immunoglobulin G|IgG]] makes the complement system more efficient
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'''Cell-Mediated'''
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==Cell-Mediated==
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*Help for macrophages
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Cell-mediated immunity provides help for macrophages. It includes [[Immunoglobulin G|IgG]] production (T-helper type II cells and [[Lymphocytes#B Cells|B cells]]), which improves phagocytosis by opsonisation. Infected [[Macrophages|macrophages]] are rescued by T-helper type I cells when phagocytosis and digestion mechanisms fail to eliminate the pathogen.
**[[Immunoglobulin G|IgG]] production (T-helper type II cells and [[Lymphocytes#B Cells|B cells]]) which improves phagocytosis by opsonisation
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**Infected [[Macrophages|macrophages]] are rescued by T-helper type I cells when phagocytosis and digestion mechanisms fail to eliminate the pathogen
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'''Extracellular Infection'''
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==Extracellular Infection==
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*Complement and phagocytosis
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The response to extracellular infection involves [[Complement|Complement]] and phagocytosis; [[Lymphocytes#B Cells|B cell]] and T helper type II cell stimulation and the production of [[Immunoglobulin M|IgM]], which activates the classical cascade. There is also class switching of [[Immunoglobulin M|IgM]] to [[Immunoglobulin G|IgG]], which is a good opsonin and targets bacterial Fcγ receptor expressed by [[Macrophages|macrophages]] and [[Neutrophils|neutrophils]].
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*[[Lymphocytes#B Cells|B cell]] and T helper type II cell stimulation
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==Vesicular Infection==
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*Production of [[Immunoglobulin M|IgM]] which activates the classical cascade
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During a vesicular infection, the infected [[Macrophages|macrophage]] secretes IL-12. IL-12 stimulates T-helper type I cells which release IFN-γ. IFN-γ then triggers the [[Macrophages|macrophages]] to kill the pathogens inside.
 
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*Class switching of [[Immunoglobulin M|IgM]] to [[Immunoglobulin G|IgG]] which is a good opsonin and targets bacterial Fcγ receptor expressed by [[Macrophages|macrophages]] and [[Neutrophils|neutrophils]]
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'''Vesicular Infection'''
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*The infected [[Macrophages|macrophage]] secretes IL-12
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*IL-12 stimulates T-helper type I cells which release IFN-γ
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*IFN-γ triggers the [[Macrophages|macrophages]] to kill the pathogens inside
      
<big>'''Also see [[Immunity to Bacteria]]'''</big>
 
<big>'''Also see [[Immunity to Bacteria]]'''</big>
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