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==Alloimmune haemolytic anaemia of the newborn==

 

An alloantigen is an antigen existing in alternative (allelic) forms in a species, thus inducing an immune response when one for is transferred to members of the same species who lack it. So alloimmune haemolytic anaemia occurs when a neonate inherits the sire's blood type and drinks colostrum from the dam, which contains antibodies against the sire and thus the neonate's red blood cells.  

==Description==

Neonatal isoerythrolysis is a disease of humans and domestic animals and has been observed in newborn cats, horses, pigs, cows and rarely in dogs. It is characterised by immune-mediated haemolytic anaemia due to ingestion of maternal colostral antibody directed against surface antigens on neonatal red blood cells.  The maternal antibodies develop in response to specific foreign blood group antigens during previous pregnancies, unmatched transfusions, and from Babesia and Anaplasma vaccinations in cattle.

 

===Feline neonatal isoerythrolysis===

Although feline neonatal isoerythrolysis (FNA) is rare, the mortality associated with it is high. FNI develops when type B blood mothers mate with type A tomcats. Type B cats have naturally occurring anti-A antibodies without prior exposure. FNI affects the A, or AB blood type kitten, born from a B blood type mother by getting anti-A antibodies when it starts suckling

 

Affected foals appear clinicall normal at birth.

 

It can naturally occur in humans (Rhesus disease) and foals (neonatal isoerytholysis) and can be induced in pigs and cattle by vaccines containing allotypic red blood cell antigens.  

It can naturally occur in humans (Rhesus disease) and foals (neonatal isoerytholysis) and can be induced in pigs and cattle by vaccines containing allotypic red blood cell antigens.