808
edits
Changes
Jump to navigation
Jump to search
no edit summary
Haemotology and biochemistry findings are usually non specific but depend on the systems affected; myositis may result in elevations in CK and AST.
Haemotology and biochemistry findings are usually non specific but depend on the systems affected; myositis may result in elevations in CK and AST.
Changes in CSF include increases in protein and nucleated cell count, predominantly mononuclear but with some neutrophils.
Definitive diagnosis is made on identification of the organism in tissues or CSF, or by the detection of oocysts in the faeces by a floatation method or PCR. ''N.caninum'' can be differenciated from ''T.gondii'' by PCR, immunohistochemistry and electron microscopy.
==Treatment==
==Treatment==
Treatment with trimethroprimsulfadiazine and pyrimethamine, or repeated doses of clindamycin hydrochloride have been successful in some cases. Treatment should be started before the signs have progressed to extensor rigidity.
Treatment with trimethroprimsulfadiazine and pyrimethamine, or repeated doses of clindamycin hydrochloride have been successful in some cases. Treatment should be started before the signs have progressed to extensor rigidity.