Changes

It is formed in the zona glomerulosa by the conversion of pregnenolone to cortisol and then to corticosterone before finally becoming aldosterone. It circulates by binding to albumin and cortisol-binding globulin. It's plasma half-life is 20 minutes. It is eventually inactivated in the liver, where it binds to glucuronic acid and is excreted in bile and urine.

It is formed in the zona glomerulosa by the conversion of pregnenolone to cortisol and then to corticosterone before finally becoming aldosterone. It circulates by binding to albumin and cortisol-binding globulin. It's plasma half-life is 20 minutes. It is eventually inactivated in the liver, where it binds to glucuronic acid and is excreted in bile and urine.

'''Regulation and action''' - It's main regulators of synthesis and secretion are; '''Renin''' and extracellular concentrations of potassium ions. Its main action is upon renal regulation and electrolyte and fluid balance. These are fully explained within the '''[[Important Hormonal Regulators of the Kidney - Anatomy & Physiology|renin-angiotensin and aldosterone system]] page.

'''Regulation and action''' - It's main regulators of synthesis and secretion are; '''Renin''' and extracellular concentrations of potassium ions. Its main action is upon renal regulation and electrolyte and fluid balance. These are fully explained within the '''[[Renin Angiotensin Aldosterone System|renin-angiotensin]] and [[Aldosterone|aldosterone system]] pages.

===='''Glucocorticoids'''====

===='''Glucocorticoids'''====