− | Lymph nodes demonstrate hyperplasia as an immunological response to antigens; cells proliferate in the cortex of the node and germinal centre activity results in multiplication of cells in the thymus-dependent area (paracortex). Newly formed plasma cells accumulate in the medullary cords and macroscopically a bulging white cortex is seen which may almost obliterate the medulla | + | Lymph nodes demonstrate hyperplasia as an immunological response to antigens; cells proliferate in the cortex of the node and germinal centre activity results in multiplication of cells in the thymus-dependent area (paracortex). Newly formed [[B cell differentiation|plasma cells]] accumulate in the medullary cords and macroscopically a bulging white cortex is seen which may almost obliterate the medulla |