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[[Image:LH Macrophage Histology.jpg|thumb|right|125px|<p>'''Macrophage'''</p><sup>© Nottingham Uni</sup>]]Macrophages are large, round cells that contain a central round nucleus and have abundant clear, often vacuolated, cytoplasm. Macrophages acts as sentinel cells, have a role in destroying bacteria, protozoa and tumour cells, and release substances that act upon other immune cells. Macrophages are phagocytic, long lived and are found throughout the body.
[[Image:LH Macrophage Histology.jpg|thumb|right|125px|<p>'''Macrophage'''</p><sup>© Nottingham Uni</sup>]]
==Introduction==
Macrophages are large, round cells that contain a central round nucleus and have abundant clear, often vacuolated, cytoplasm. Macrophages acts as sentinel cells, have a role in destroying bacteria, protozoa and tumour cells, and release substances that act upon other immune cells. Macrophages are phagocytic, long lived and are found throughout the body.
==Development==
==Development==
Macrophages are either derived from blood borne [[Monocytes|monocytes]] which have migrated into tissue and differentiated, or from dividing macrophages within the tissue.
Macrophages are either derived from blood borne [[Monocytes|monocytes]] which have migrated into tissue and differentiated, or from dividing macrophages within the tissue.