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[[Image:LH Macrophage Histology.jpg|thumb|right|125px|<p>'''Macrophage'''</p><sup>© Nottingham Uni</sup>]]
[[Image:LH Macrophage Histology.jpg|thumb|right|125px|<p>'''Macrophage'''</p><sup>© Nottingham Uni</sup>]]
==Introduction==
==Introduction==
Macrophages are large, round cells that contain a central round nucleus and have abundant clear, often vacuolated, cytoplasm. Macrophages acts as sentinel cells, have a role in destroying bacteria, protozoa and tumour cells, and release substances that act upon other immune cells. Macrophages are phagocytic, long lived and are found throughout the body.
Macrophages are large, round cells that contain a central round nucleus and have abundant clear, often vacuolated, cytoplasm. Macrophages acts as sentinel cells; they have a role in destroying bacteria, protozoa and tumour cells, and release substances that act upon other immune cells. Macrophages are phagocytic, long lived and are found throughout the body.
==Development==
==Development==
Macrophages are either derived from blood borne [[Monocytes|monocytes]] which have migrated into tissue and differentiated, or from dividing macrophages within the tissue.
Macrophages are either derived from blood borne [[Monocytes|monocytes]] which have migrated into tissue and differentiated, or from dividing macrophages within the tissue.