Changes

==TCR-MHC Interaction==

==TCR-MHC Interaction==

[[Image:MHC T cell Interaction.jpg|thumb|right|150px|Molecules of T lymphocyte recognition - Copyright Prof Dirk Werling DrMedVet PhD MRCVS]]

[[Image:MHC T cell Interaction.jpg|thumb|right|200px|Molecules of T lymphocyte recognition - Copyright Prof Dirk Werling DrMedVet PhD MRCVS]]

* Only peptide associated with self-MHC will interact with and activate [[Lymphocytes#T Cells|T cells]]

Only peptide associated with self-MHC will interact with and activate [[T cells]], which cannot be activated by a peptide on a foreign cell.

** [[Lymphocytes#T Cells|T cells]] cannot be activated by a peptide on a foreign cell

T cells will react against foreign MHC molecules and this is the basis of graft rejection

** [[Lymphocytes#T Cells|T cells]] will react against foreign MHC molecules

*** This is the basis of graft rejection

[[Image:Location of Polymorphic Residues 1.jpg|thumb|right|150px|Location of Polymorphic Residues - Copyright Prof Dirk Werling DrMedVet PhD MRCVS]]

[[Image:Location of Polymorphic Residues 1.jpg|thumb|right|150px|Location of Polymorphic Residues - Copyright Prof Dirk Werling DrMedVet PhD MRCVS]]