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[[Image:LH Developing Erythrocyte Histology.jpg|right|thumb|200px|'''Developing erythrocytes''' ©RVC 2008]]
==Introduction==
==Introduction==
[[Erythrocytes|Erythrocytes]] contain no nucleus and are thus only produced from stem cells. During the fetal stage production is in both the [[Liver - Anatomy & Physiology|liver]] and [[Spleen - Anatomy & Physiology|spleen]] however production is transferred to the [[Bone Marrow - Anatomy & Physiology|bone marrow]] ([[Bone Marrow - Anatomy & Physiology#Red marrow|red marrow]]) in the final stages of gestation. Initially erythropoiesis occurs in all bones, however after puberty production is limited to membranous bones (ribs, vertebrae, pelvic bones etc.) as in the long bones adipose tissue replaces red marrow.
[[Erythrocytes|Erythrocytes]] contain no nucleus and are thus only produced from stem cells. During the fetal stage production is in both the [[Liver - Anatomy & Physiology|liver]] and [[Spleen - Anatomy & Physiology|spleen]] however production is transferred to the [[Bone Marrow - Anatomy & Physiology|bone marrow]] ([[Bone Marrow - Anatomy & Physiology#Red marrow|red marrow]]) in the final stages of gestation. Initially erythropoiesis occurs in all bones, however after puberty production is limited to membranous bones (ribs, vertebrae, pelvic bones etc.) as in the long bones adipose tissue replaces red marrow.
Reticulocytes and mature [[Erythrocytes|erythrocytes]] leave the [[Bone Marrow - Anatomy & Physiology|bone marrow]] by ‘squeezing’ through the capillary endothelial cells. Precursor to these stages cannot change shape and therefore remain in the [[Bone Marrow - Anatomy & Physiology|bone marrow]].
Reticulocytes and mature [[Erythrocytes|erythrocytes]] leave the [[Bone Marrow - Anatomy & Physiology|bone marrow]] by ‘squeezing’ through the capillary endothelial cells. Precursor to these stages cannot change shape and therefore remain in the [[Bone Marrow - Anatomy & Physiology|bone marrow]].
==Development==
==Development==
[[Erythrocytes|Erythrocyte]] development is divided into several stages and at each stage the cell will divide several times. As [[Bone Marrow - Anatomy & Physiology|bone marrow]] does not act as storage, all erythrocytes produced are immediately released into the circulation.
[[Erythrocytes|Erythrocyte]] development is divided into several stages and at each stage the cell will divide several times. As [[Bone Marrow - Anatomy & Physiology|bone marrow]] does not act as storage, all erythrocytes produced are immediately released into the circulation.
===Stem cell ===
===Stem cell ===