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NDV affects the gastrointestinal, respiratory and nervous systems and clinical signs reflect the system(s) affected. Clinical signs are usually acute and may appear throughout the flock within 2-12 days with young birds particularly susceptible to the disease. Signs in affected birds may be variable and a subclinical form of the disease can occur, which may only be suspected following a drop in egg production. Respiratory signs may include dyspnoea, sneezing, nasal discharge and coughing and are common with low virulence infections. Neurological signs such as tremors, paralysis, circling and depression may accompany respiratory signs and are often seen in cormorants and exotic bird species. Pigeons frequently display neurological signs accompanied by diarrhoea.
 
NDV affects the gastrointestinal, respiratory and nervous systems and clinical signs reflect the system(s) affected. Clinical signs are usually acute and may appear throughout the flock within 2-12 days with young birds particularly susceptible to the disease. Signs in affected birds may be variable and a subclinical form of the disease can occur, which may only be suspected following a drop in egg production. Respiratory signs may include dyspnoea, sneezing, nasal discharge and coughing and are common with low virulence infections. Neurological signs such as tremors, paralysis, circling and depression may accompany respiratory signs and are often seen in cormorants and exotic bird species. Pigeons frequently display neurological signs accompanied by diarrhoea.
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Post mortem lesions include sacculitis, tracheitis and petechiae on the serous membranes. The proventricular mucosa is frequently haemorrhagic with necrotic plaques. In birds infected with the less virulent strains of NDV the lesions may be restricted to congestion of the respiratory tract.  
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Post mortem lesions include sacculitis, tracheitis and petechiae on the serous membranes. The proventricular mucosa is frequently haemorrhagic with necrotic plaques. In birds infected with the less virulent strains of NDV the lesions may be restricted to congestion of the respiratory tract and thickening and opacification of the air sacs.
    
[[Image:Newcastle Disease.jpg|150px|thumb|right|''Newcastle Disease'' <br> L. Mahin, Wikimedia Commons]]
 
[[Image:Newcastle Disease.jpg|150px|thumb|right|''Newcastle Disease'' <br> L. Mahin, Wikimedia Commons]]
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