Changes

==Introduction==

==Introduction==

DIC, also known as consumptive coagulopathy, is a condition where the coaguation and fibrinolytic cascades are out of control as a result of systemic [[Thrombosis|thrombosis]].  There is widespread clotting throughout the body with fibrinolysis and then a paradoxical [[Haemorrhage - Pathology|haemorrhage]]. It is often recognised in dogs but rarely in cats.

DIC, also known as consumptive coagulopathy, is a condition where the coaguation and fibrinolytic cascades are out of control as a result of systemic [[Thrombosis|thrombosis]].  There is widespread clotting throughout the body with fibrinolysis and then a paradoxical [[Haemorrhage - Pathology|haemorrhage]]. It is often recognised in dogs but rarely in cats.

DIC always occurs secondary to another disease.

DIC always occurs as a secondary condition with an underlying cause.  

There are multiple aetiologies for DIC, however, once the cascade is under way the disease process is essentially the same.  Causes include:

There are multiple aetiologies for DIC; once the cascade is under way the process is essentially the same.  Causes include:

*Sepsis, particularly gram negative organisms.

*Sepsis, particularly gram negative organisms.

*Obstetric complications; chemicals released from the uterus.

*Obstetric complications; chemicals released from the uterus.

*Tissue trauma e.g. burns.

*Tissue trauma e.g. burns.

*Liver disease.

*Liver disease.

*[[:Category:Transfusion Medicine|Transfusion]] reaction.

*[[:Category:Transfusion Medicine|Transfusion]] reactions.

*Neoplasia.

*Neoplasia.

*Certain snake venoms.

*Certain snake venoms.

*Acute haemolytic crises

*Acute haemolytic crises.

*Infectious( Viral, bacterial, protozoal) and post-infectious immunologic reactions.

*Infectious( Viral, bacterial, protozoal) and post-infectious immunologic reactions.