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→Introduction
==Introduction==
==Introduction==
The absolute or relative deficiency of vitamin K can give rise to defective coagulation.
The absolute or relative deficiency of vitamin K can give rise to defective coagulation.
[[Anticoagulant Rodenticide Toxicity|Anticoagulant rodenticide toxiticy]] is one of the most common causes of acquired coagulopathy in small animals. Warfarin itself has a short half-life and a fairly low toxicity in non-rodent species, so unless large or repeated doses are consumed clinical bleeding is rare. However, the second generation anticoagulant rodenticides are far more potent, and it is possible for a domestic animal to acquire secondary poisoning by ingesting a killed rodent<sup>1</sup>. Dogs are most commonly effected, but predator species such as cats and owls do occaionally suffer from secondary poisonings.
[[Anticoagulant Rodenticide Toxicity|Anticoagulant rodenticide toxiticy]] is one of the most common causes of acquired coagulopathy in small animals. Warfarin itself has a short half-life and a fairly low toxicity in non-rodent species, so unless large or repeated doses are consumed clinical bleeding is rare. However, the second generation anticoagulant rodenticides are far more potent, and it is possible for a domestic animal to acquire secondary poisoning by ingesting a poisoned rodent<sup>1</sup>. Dogs are most commonly effected, but predator species such as cats and owls do occaionally suffer from secondary poisonings.
The clotting factors - factor VII, factor XI and factors II and X in the extrinsic, intrinsic and common pathways respectively are dependent on Vitamn K when activated by the coagulation cascade.
The clotting factors - factor VII, factor XI and factors II and X in the extrinsic, intrinsic and common pathways respectively are dependent on Vitamn K when activated by the coagulation cascade.