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Also known as: coagulation profile, clotting profile, clotting tests, tests of haemostasis.

Also known as: '''''coagulation profile — clotting profile — clotting tests — tests of haemostasis

==Introduction==

==Introduction==

===Haemostasis===

===[[Haemostasis]]===

[[Image:Coagulation Cascade.jpg|thumb|right|350px|oagulation cascade. Source: Wikimedia Commons; Author: Joe D (2007)]]

[[Image:Coagulation Cascade.jpg|thumb|right|350px|oagulation cascade. Source: Wikimedia Commons; Author: Joe D (2007)]]

Normally, haemostastis is maintained by three key events. The first stage, primary haemostasis, involves platelets and the blood vessels themselves. It is triggered by injury to a vessel, and platelets become activated, adhere to endothelial connective tissue and aggregate with other platelets. A fragile plug is thus formed which helps to stem haemorrhage from the vessel. Substances are released from platelets during primary haemostasis. Vasoactive compounds give vasoconstriction, and other mediators cause continued platelet activation and aggregation, as well as contraction of the platelet plug. Primary haemostasis ceases once defects in the vessels are sealed and bleeding stops.

Normally, haemostastis is maintained by three key events. The first stage, primary haemostasis, involves platelets and the blood vessels themselves. It is triggered by injury to a vessel, and platelets become activated, adhere to endothelial connective tissue and aggregate with other platelets. A fragile plug is thus formed which helps to stem haemorrhage from the vessel. Substances are released from platelets during primary haemostasis. Vasoactive compounds give vasoconstriction, and other mediators cause continued platelet activation and aggregation, as well as contraction of the platelet plug. Primary haemostasis ceases once defects in the vessels are sealed and bleeding stops.

Although the test is simple to perform, interpretation may be challenging. This is because other small fragments involved in the homeostasis of fibrinogen and fibrin are measured by the test in addition to ''bona fide'' fibrin degradation products. In general, an increase in FDP correspons to increased fibrinolysis. This can be due to a local problem of fibrin generation such as thrombosis, trauma or chronic bleeding, or be related to a systemic process, usually DIC³.

Although the test is simple to perform, interpretation may be challenging. This is because other small fragments involved in the homeostasis of fibrinogen and fibrin are measured by the test in addition to ''bona fide'' fibrin degradation products. In general, an increase in FDP correspons to increased fibrinolysis. This can be due to a local problem of fibrin generation such as thrombosis, trauma or chronic bleeding, or be related to a systemic process, usually DIC³.

==Links==

==Links==

#Howard, M R and (2008) '''Haematology: an illustrated colour text''', ''Elsevier Health Sciences''.

#Howard, M R and (2008) '''Haematology: an illustrated colour text''', ''Elsevier Health Sciences''.

[[Category:To Do - Blood]][[Category:To Do - Lizzie]] [[Category:To Do - Review]]

[[Category:Haemostasis]][[Category:To Do - Lizzie]] [[Category:To Do - Review]]