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Drug-induced and heavy metal damage to the vascular system does occur, although the mechanisms are not clearly understood. Examples include lead, bismuth, mercury, iodides, fluorides, chlorinated hydrocarbon pesticides and salicylates.
 
Drug-induced and heavy metal damage to the vascular system does occur, although the mechanisms are not clearly understood. Examples include lead, bismuth, mercury, iodides, fluorides, chlorinated hydrocarbon pesticides and salicylates.
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Vascular fragility can occur as a consequence of an underlying disease state, which is seen in allergy or anaphylactic reactions, connective tissue diseases such as Ehlers-Danlos syndrome in dogs, [[DM|diabetes mellitus]] and [[:Category:Antibody Mediated Autoimmune Diseases|antibody-antigen complex reactions]].
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Vascular fragility can occur as a consequence of an underlying disease state, which is seen in [[Type III Hypersensitivity|allergy]] or anaphylactic reactions, connective tissue diseases such as Ehlers-Danlos syndrome in dogs, [[DM|diabetes mellitus]] and [[:Category:Antibody Mediated Autoimmune Diseases|antibody-antigen complex reactions]].
    
==Platelet dysfunction==
 
==Platelet dysfunction==
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