Injection of ketamine and xylazine into the caudal thigh caused self-mutilation of the digits in two laboratory rabbits (Beyers et al 1991, cited by Harcourt Brown 2002). Clinical signs skin were irritation with posterior extension of the leg during ambulation and shaking of the paw with each step. Sciatic axonal degeneration was seen on necropsy. | Injection of ketamine and xylazine into the caudal thigh caused self-mutilation of the digits in two laboratory rabbits (Beyers et al 1991, cited by Harcourt Brown 2002). Clinical signs skin were irritation with posterior extension of the leg during ambulation and shaking of the paw with each step. Sciatic axonal degeneration was seen on necropsy. |