Changes

*[[Anaemia - Introduction|Anaemia]] with a reactive [[Neutrophilia|neutrophilia]] and [[Monocytosis|monocytosis]] if the haemorrhage is severe.

*[[Anaemia - Introduction|Anaemia]] with a reactive [[Neutrophilia|neutrophilia]] and [[Monocytosis|monocytosis]] if the haemorrhage is severe.

Severe platelet deficiencies may be managed with transfusions of whole blood or, in the USA, with transfusions of platelet cryoprecipitate.  With both techniques however, it is likely that the transfused platelets have only a short half life in the recipient.   

Severe platelet deficiencies may be managed with transfusions of whole blood or, in the USA, with transfusions of platelet cryoprecipitate - this helps to control the anaemia which occurs as a consequence of haemorrhage and which is the life threatening sympton that required correction (rather than the thrombocytopenia).  With both techniques however, it is likely that the transfused platelets have only a short half life in the recipient.   

The use of Vincristine (a drug also used in chemotherapy for neoplasia) has been advocated in cases of thrombocytopaenia as it causes the release of immature platelets from the bone marrow.

The use of Vincristine (a drug also used in chemotherapy for neoplasia) has been advocated in cases of thrombocytopaenia as it increases the rate of fragmentation of megakaryocytes and decreases the descruction of platelets by macrophages. A single intravenous dose is usually given.

==Literature Search==

==Literature Search==