Changes

==Introduction==

==Introduction==

Ketosis occurs in starvation and also in [[Diabetes Mellitus|diabetes mellitus]], [[Ketosis of Cattle|Ketosis of cattle]] and [[Pregnancy Toxaemia|Pregnancy toxaemia of sheep]]. Basically, no carbohydrates are metabolised, in starvation none are available and in diabetes mellitus because there is no insulin present to allow glucose transport into cells.

Ketosis occurs in starvation and also in [[Diabetes Mellitus|diabetes mellitus]], [[Ketosis of Cattle|ketosis of cattle]] and [[Pregnancy Toxaemia|pregnancy toxaemia of sheep]]. Basically, no carbohydrates are metabolised, in starvation none are available and in diabetes mellitus because there is no insulin present to allow glucose transport into cells.

When carbohydrates are not available the body produces energy via the metabolism of fat. Fatty changes can be seen in the liver and kidney following deposition of the mobilised fat.

When carbohydrates are not available the body produces energy via the metabolism of fat. Fatty changes can be seen in the liver and kidney following deposition of the mobilised fat.

This results in an accumulation of ketone bodies (B-hydroxybutyric acid, acetoacetic acid and acetone) in the blood and other tissues. Two of the ketone bodies are acids resulting in a metabolic acidosis hence the name ketoacidosis.

This results in an accumulation of ketone bodies (B-hydroxybutyric acid, acetoacetic acid and acetone) in the blood and other tissues. Two of the ketone bodies are acids resulting in a metabolic acidosis hence the name ketoacidosis.