[[Lymphosarcoma]] - (aka Lymphoma) is caused by malignant clonal expansion of lymphoid cells and most commonly arises from lymphoid tissues including the [[Bone Marrow|bone marrow]], [[Thymus - Anatomy & Physiology|thymus]], [[Lymph Nodes - Anatomy & Physiology|lymph nodes]] and [[Spleen - Anatomy & Physiology|spleen]]. Lymphoma is documented to be the most common haematopoietic [[Neoplasia - Pathology|neoplasm]] in dogs.
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In the '''dog''', multicentric lymphoma is most common representing 80% of cases. Alimentary, cutaneous, mediastinal and extranodal sites are less common. Additionally the majority of lymphoma cases in dogs are of the B-cell immunophenotype.
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In '''cats''' following the introduction of widespread [[Feline Leukaemia Virus|FeLV]] testing and [[vaccines|vaccination]] the most common type of lymphoma affecting cats is alimentary when previously it had been the mediastinal and multicentric forms.
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Only 10% of lymphoma cases in cats are now associated with FeLV.