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These agents are '''highly protein-bound''' and should be used with care in hypoalbuminemia and concomitantly with other highly protein-bound drugs. Benzodiazepines should also be used with caution in animals with impaired hepatic function and concurrently with agents that also undergo hepatic metabolism, ''e.g.'' [[Macrolides and Lincosamides|erythromycin]], [[Gastroprotective Drugs#Histamine (H2) Receptor Antagonists|cimetidine]]. Zolazepam is only available in a fixed combination with the dissociative anaesthetic [[Anaesthetics - Donkey#Ketamine and Tiletamine|tiletamine]].
These agents are '''highly protein-bound''' and should be used with care in hypoalbuminemia and concomitantly with other highly protein-bound drugs. Benzodiazepines should also be used with caution in animals with impaired hepatic function and concurrently with agents that also undergo hepatic metabolism, ''e.g.'' [[Macrolides and Lincosamides|erythromycin]], [[Gastroprotective Drugs#Histamine (H2) Receptor Antagonists|cimetidine]]. Zolazepam is only available in a fixed combination with the dissociative anaesthetic [[Anaesthetics - Donkey#Ketamine and Tiletamine|tiletamine]].
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==References==
==References==