Guaifenesin, a centrally acting skeletal muscle relaxant with only mild sedative and analgesic effects, can be administered intravenously to donkeys in combination with xylazine and ketamine for extended periods of general anaesthesia (Matthews and Taylor, 2000). Careful monitoring of the depth of anaesthesia is essential, particularly because donkeys are more sensitive | Guaifenesin, a centrally acting skeletal muscle relaxant with only mild sedative and analgesic effects, can be administered intravenously to donkeys in combination with xylazine and ketamine for extended periods of general anaesthesia (Matthews and Taylor, 2000). Careful monitoring of the depth of anaesthesia is essential, particularly because donkeys are more sensitive |