− | Stimulation of beta-receptors leads to stimulation of adenylate cyclase, which generates intracellular cyclic AMP. This in turn has many intracellular effects, including increasing the rate and magnitude of the contractions in intracellular calcium fibres. This has a positive inotrope (increased myocardial contractility which increases cardiac output), positive chronotrope (increased heart rate), and positive luisitrope (improved diastolic relaxation) effect, and stimulates renin release from the Juxtaglomerular apparatus (JGA). | + | Stimulation of beta-receptors leads to stimulation of adenylate cyclase, which generates intracellular cyclic AMP. This in turn has many intracellular effects, including increasing the rate and magnitude of the contractions in intracellular calcium fibres. This has a positive inotrope (increased myocardial contractility which increases cardiac output), positive chronotrope (increased heart rate), and positive luisitrope (improved diastolic relaxation) effect, and stimulates renin release from the [[Reabsorption_and_Secretion_Along_the_Distal_Tubule_and_Collecting_Duct_-_Anatomy_%26_Physiology#Juxtaglomerular_Apparatus|Juxtaglomerular apparatus (JGA)]]. |