Changes

*decreased chloride delivery to the macula densa is detected by chemoreceptors - a drop in glomerular filtration rate (GFR) detected as a drop in chloride presented at the macula densa leads to increased reabsorption in the proximal convoluted tubule.

*decreased chloride delivery to the macula densa is detected by chemoreceptors - a drop in glomerular filtration rate (GFR) detected as a drop in chloride presented at the macula densa leads to increased reabsorption in the proximal convoluted tubule.

Renin then leads to the [[Renin_Angiotensin_Aldosterone_System#The_System|cleavage]] of circulating Angiotensinogen (produced by the liver) to angiotensin I, and then [[Angiotensin Converting Enzyme(ACE) - Renal Anatomy & Physiology|angiontensin converting enzyme (ACE)]] catalyses the production of angiotensin II from angiotensin I - this occurs mainly in the lungs. ACE is bound to endothelial cells throughout the vascular system. Angiotensin II acts as a stimulus to [[Aldosterone|aldosterone]] release from the zona glomerulosa of the adrenal cortex, which in turn leads to sodium and water retention in the cortical collecting duct of the renal tubule.

Renin then leads to the [[Renin_Angiotensin_Aldosterone_System#The_System|cleavage]] of circulating Angiotensinogen (produced by the liver) to angiotensin I, and then [[Angiotensin Converting Enzyme(ACE) - Renal Anatomy & Physiology|angiontensin converting enzyme (ACE)]] catalyses the production of angiotensin II from angiotensin I - this occurs mainly in the lungs. ACE is bound to endothelial cells throughout the vascular system. Angiotensin II acts as a stimulus to [[Aldosterone|aldosterone]] release from the zona glomerulosa of the [[Adrenal Glands - Anatomy & Physiology|adrenal cortex]], which in turn leads to sodium and water retention in the cortical collecting duct of the renal tubule.

'''NOTE''' This system is responsible for the long-term maintenance of blood pressure, but is also activated very rapidly in the presence of hypotension.

'''NOTE''' This system is responsible for the long-term maintenance of blood pressure, but is also activated very rapidly in the presence of hypotension.