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==Introduction==
 
==Introduction==
 
[[Image:Kinetics of FeLV 2.jpg|thumb|right|200px|Kinetics of FeLV - Copyright Dr Brian Catchpole BVetMed PhD MRCVS]]
 
[[Image:Kinetics of FeLV 2.jpg|thumb|right|200px|Kinetics of FeLV - Copyright Dr Brian Catchpole BVetMed PhD MRCVS]]
*Oncogenic retrovirus
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FeLV is an ncogenic retrovirus which causes neoplasia (lymphoma), myelosuppression (anaemia) and immunosuppression (of [[Lymphocytes#T cells|T cells]]). Three different strains are currently recognised:  
*Causes neoplasia (lymphoma), myelosuppression (anaemia) and immunosuppression (of [[Lymphocytes#T cells|T cells]])
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*FeLV-A -natural strain
*2 strains:  
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*FeLV-B which formed through FeLV-A recombining with endogenous retroviral sequences in the feline genome.
**FeLV-A
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*FeLV-C which formed from the spontaneous mutation of FeLV-A
***Natural strain
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**FeLV-B  
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The virus replicates in the oropharyngeal lymphoid tissue causing a viraemia (virus circulating in the bloodstream) which then spreads to the systemic lymphoid tissue.
***Formed through FeLV-A recombining with endogenous retroviral sequences in the feline genome
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***Increases the risks of lymphoma
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**FeLV-C
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***Formed from the spontaneous mutation of FeLV-A
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***Is more myelosuppressive
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*Virus replicates in the oropharyngeal lymphoid tissue causing a viraemia (virus circulating in the bloodstream) which then spreads to the systemic lymphoid tissue
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*Shed in saliva
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*Passed by oronasal route, e.g. mutual grooming
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*Kittens between 6 weeks and 6 months are most susceptible
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*60% of cats will become immune to the disease and recover
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*Cats that are persistently viraemic will progress to develop FeLV-associated diseases
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*Some cats will become viraemic again if treated with corticosteroids or stressed if the infection lies dormant in the [[Bone Marrow - Anatomy & Physiology|bone marrow]]
      
==Pathogenesis==
 
==Pathogenesis==
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