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There are several possible causes of primary hypoadrenocorticism, including:  
 
There are several possible causes of primary hypoadrenocorticism, including:  
 
*'''Adrenal atrophy''' is thought to be an autoimmune disease caused by a type IV immune response.  Affected animals have an increased risk of developing other immune-mediated diseases, including [[Immune Mediated Haemolytic Anaemia|immune-mediated haemolytic anaemia]]. Grossly, the adrenal glands are small, difficult to locate and they are dark brown on cut sections. Histological analysis reveals the presence of an infiltrate of lymphocytes, plasma cells and macrophages.   
 
*'''Adrenal atrophy''' is thought to be an autoimmune disease caused by a type IV immune response.  Affected animals have an increased risk of developing other immune-mediated diseases, including [[Immune Mediated Haemolytic Anaemia|immune-mediated haemolytic anaemia]]. Grossly, the adrenal glands are small, difficult to locate and they are dark brown on cut sections. Histological analysis reveals the presence of an infiltrate of lymphocytes, plasma cells and macrophages.   
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[[Image:Adrenal necrosis.jpg|thumb|125px|Histological section of an adrenal gland undergoing necrosis<br><small>A. Jefferies 2008</small>]]
   
[[Image:Adrenal necrosis2.jpg|thumb|125px|Image of an adrenal gland undergoing necrosis.  Note the areas of haemorrhage within the cortex of the gland.<br><small>A. Jefferies 2008</small>]]
 
[[Image:Adrenal necrosis2.jpg|thumb|125px|Image of an adrenal gland undergoing necrosis.  Note the areas of haemorrhage within the cortex of the gland.<br><small>A. Jefferies 2008</small>]]
  
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