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− | '''Cholangitis''' is the inflammation of the biliary tract. '''Cholangiohepatitis''' is the inflammation of the biliary tract and the surrounding hepatic parenchyma. It is typically categorised into [[Cholangitis, Neutrophilic|Neutrophilic Cholangitis]] and [[Cholangitis, Lymphocytic|Lymphocytic Cholangitis]].
| + | ==Introduction== |
| + | Cholangitis describes an inflammation of the biliary tract. Cholangiohepatitis describes the inflammation of the biliary tract and the surrounding hepatic parenchyma. It is typically categorised into [[Cholangitis, Neutrophilic|Neutrophilic Cholangitis]] and [[Cholangitis, Lymphocytic|Lymphocytic Cholangitis]]. |
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| + | ==Signalment== |
| + | Cholangitis is common in cats, where a periportal hepatocellular necrosis is seen together with |
| + | the presence of neutrophils in the portal area. Cats can be acutely or chronicaly affected, and |
| + | male, pure bred cats are most overly prepresented. |
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| + | The condition is also seen in calves as a secondary condition to bacterial infection, such as Salmonella. |
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− | *Inflammation of the bile ducts | + | ===Causes=== |
− | | + | *ascending infections from the intestine where stasis of bile flow has developed |
− | **common in cats | + | *associated with organisms excreted via the bile such as salmonellosis infection in calves |
− | **calves eg ''Salmonella sp.''
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− | ===Causes=== | + | ==Laboratory Findings== |
− | *ascending infections from the intestine
| + | Raised ALT and serum bilirubin levels. |
− | **requires stasis of bile flow to develop
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− | *associated with organisms excreted via the bile
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− | **salmonellosis infection in calves
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− | ==Cats==
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− | ***cholangitis
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− | ***periportal hepatocellular necrosis
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− | ***neutrophils in the portal areas
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− | ***acute or chronic.
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− | ***Usually male, pure bred
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− | *** Cats more ill than lymphocytic portal hepatitis.
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− | ***Higher ALT and serum bilirubin levels.
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− | ===Chronic lymphocytic cholangitis=== | + | ==Histology== |
− | *mature cats
| + | Lymphocytic infiltration of the portal areas is seen, with mild fibrosis and biliary hyperplasia. |
− | ====Microscopically====
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− | *lymphocytic infiltration of the portal areas
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− | *mild fibrosis
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− | *biliary hyperplasia
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| ==Test yourself with the Liver Pathology Flashcards== | | ==Test yourself with the Liver Pathology Flashcards== |
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| [[Liver_Flashcards_-_Pathology|Liver Pathology Flashcards]] | | [[Liver_Flashcards_-_Pathology|Liver Pathology Flashcards]] |
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