Very severe diseases that deplete the neutrophils may also exhaust the reserve supply of these cells in the bone marrow. In such situations, there is a neutropenia without band cells in the circulation and degenerate neutrophils are seen - this is known as a degenerative right shift. Some severe localised infections (including pyometras) may cause a neutrophilia of much greater magnitude than is usually observed. This so-called '''leukaemoid response''' may precede a right shift.
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Very severe diseases that deplete the neutrophils may also exhaust the reserve supply of these cells in the bone marrow. In such situations, there is a neutropenia without band cells in the circulation and degenerate neutrophils are seen - this is known as a degenerative right shift. Degenerate neutrophils have a highly segmented nucleus, often in the shape of the 'Victoria Cross'. Some severe localised infections (including pyometras) may cause a neutrophilia of much greater magnitude than is usually observed. This so-called '''leukaemoid response''' may precede a right shift.