Changes

==Clinical Significance==

==Clinical Significance==

The competence of  enterohepatic circulation is usually assessed dynamically by performing a bile acid stimulation test; the patient is fasted for 12 hours and then fed a test meal and the serum bile acid concentration are measured before and two hours after the meal.  The post-prandial measurement may be '''elevated''' in the following conditions:

The competence of  enterohepatic circulation is usually assessed dynamically by performing a bile acid stimulation test; the patient is fasted for 12 hours and then fed a test meal and the serum bile acid concentration are measured before and two hours after the meal.  The post-prandial measurement may be '''elevated''' in the following conditions:

*'''Hepatobiliary disease''', but the type of disease cannot be determined from this finding alone.

*'''Hepatobiliary disease'''; this is a non specific test for hepatobiliary disease.

*'''Cholestasis''', including the mild cholestasis that occurs due to hepatic hydropic change in [[Canine Hyperadrenocorticism - Cushing's Disease|hyperadrenocorticism]] in dogs and [[Biliary Tract - Obstruction|extra-hepatic biliary obstruction]].

*'''Cholestasis''', including the mild cholestasis that occurs due to hepatic hydropic change in [[Canine Hyperadrenocorticism - Cushing's Disease|hyperadrenocorticism]] in dogs and [[Biliary Tract - Obstruction|extra-hepatic biliary obstruction]].

*[[Portosystemic Shunt|'''Portosystemic shunts''']] or [[Hepatic Microvascular Dysplasia|'''microvascular dysplasia''']], in which the portal blood is directed into the systemic circulation, disrupting the enterohepatic circulation.

*[[Portosystemic Shunt|'''Portosystemic shunts''']] or [[Hepatic Microvascular Dysplasia|'''microvascular dysplasia''']], in which the portal blood is directed into the systemic circulation, disrupting the enterohepatic circulation.