Failures do occur and should be reported on the VMD [[[http://www.vmd.gov.uk/ 'yellow form' MLA252A]|'yellow forms']]. Circumstances leading to vaccine failure include:
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*Recipient is already infected with the virus or is immunosuppressed and unable to mount an immune response.
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*Recipient is already infected with the virus or immunosuppressed
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*Break down of the '''cold-chain''' during transport (incorrect storage of vaccines requiring refridgeration)
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*Break down of the '''cold-chain''' during transport