Changes

Adjuvants are used with vaccines containing inactivated organisms which alone would only stimulate a weak immune response. Some adjuvants create a depot of antigen at the injection site allowing a steady flow of antigen into the afferent lymph, while others stimulate the immune system to amplify the adaptive immune response to antigens e.g. pathogen-associated molecular patterns (PAMPs). PAMP-like adjuvants assist naive [[T cells|T cell]] priming.

Adjuvants are used with vaccines containing inactivated organisms which alone would only stimulate a weak immune response. Some adjuvants create a depot of antigen at the injection site allowing a steady flow of antigen into the afferent lymph, while others stimulate the immune system to amplify the adaptive immune response to antigens e.g. pathogen-associated molecular patterns (PAMPs). PAMP-like adjuvants assist naive [[T cells|T cell]] priming.

Different subtypes of [[Lymphocytes#Helper CD4+|T helper cells]] are stimulated by different adjuvants, for example:

Different subtypes of [[T cell differentiation|T helper cells]] are stimulated by different adjuvants, for example:

*Aluminium salts generate bias [[T cell differentiation#TH2 Cells|T helper II]] responses for [[Immunoglobulins|'''antibody''']]-mediated immunity

*Aluminium salts generate bias [[T cell differentiation#TH2 Cells|T helper II]] responses for antibody-mediated immunity

*Killed mycobacteria generate IL-12 producing good '''cell'''-mediated immunity

*Killed mycobacteria generate IL-12 producing good '''cell'''-mediated immunity