Changes

==Description==

==Description==

Creatinine is formed as a degradation product of creatine kinase, an enzyme mainly found in skeletal muscle.  Its rate of production is proportional to the muscle mass of the animal and very muscular animals and entire male animals often have higher serum concentrations than others.  It is filtered passively into the glomerular filtrate and it is not reabsorbed so the urine creatinine concentration can be used to standardise the concentrations of other metabolites in urine, as in the calculation of the urine protein: creatinine ratio (UPC) or urine corticoid: creatinine ratio (UCCR) for [[Canine Hyperadrenocorticism - Cushing's Disease|hyperadrenocorticism]].

Creatinine is formed as a degradation product of creatine kinase, an enzyme mainly found in skeletal muscle.  Its rate of production is proportional to the muscle mass of the animal and very muscular animals and entire male animals often have higher serum concentrations than others.  It is filtered passively into the glomerular filtrate and it is not reabsorbed so the urine creatinine concentration can be used to standardise the concentrations of other metabolites in urine, as in the calculation of the urine protein: creatinine ratio (UPC) or urine corticoid: creatinine ratio (UCCR) for [[Hyperadrenocorticism|hyperadrenocorticism]].

==Clinical Significance==

==Clinical Significance==