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==Introduction==
 
==Introduction==
Pulmonary Infiltration with Eosinophilia is a broad term describing an inflammatory lung disease in which the predominant infiltrating cell is the eosinophil. It is thought to be an immune mediated condition where the airway abnormalities are a consequence of a hypersensitivity reaction to an unidentified allergen such as microfilariae of heartworms, lungworms, chronic bacterial or fungal infections (eg, histoplasmosis, aspergillosis), viruses, external antigens, and unknown precipitating factors
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Pulmonary Infiltration with Eosinophilia (PIE) is a broad term describing an inflammatory lung disease in which the predominant infiltrating cell is the eosinophil. It is thought to be an immune mediated condition where the airway abnormalities are a consequence of a hypersensitivity reaction to an unidentified allergen such as microfilariae of heartworms, lungworms, chronic bacterial or fungal infections (eg, histoplasmosis, aspergillosis), viruses, external antigens, and unknown precipitating factors.
 
<br> '''Eosinophillic pulmonary granulomatosis''' is a severe type of PIE seen in dogs and is characterzied by the development of nodules and hilar lymphadenopathy. It is most often associted with a hypersensitivity reaction to microfilarie in heartworm infection.  
 
<br> '''Eosinophillic pulmonary granulomatosis''' is a severe type of PIE seen in dogs and is characterzied by the development of nodules and hilar lymphadenopathy. It is most often associted with a hypersensitivity reaction to microfilarie in heartworm infection.  
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==History & Clincial signs==
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Eosinophillic lung diseases are seen in young and older dogs. It is rare in the Cat.
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<br> Affected dogs usually present because of slowly progressive respiratory signs such as a cough, increased respiratory effort and exercise intolerance. Systemic signs are rarely present but may include anorecia and weight loss. There may be a history of a recurring cough which is unresponsive to antibiotics but often responsive to corticosteroid therapy. The clinical signs may be seasonal in appearance.
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==Diagnosis==
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===Physical examination===
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Physical examination is largely normal. Thoracic auscultation may reveal crackles or expiratory wheezes.
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===Radiography===
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The most comon radiographic finding is a diffuse ''Interstitial lung pattern'', a bronchial and/or alveolar pattern may also be visible. Eosinophilic Pulmonary Granulmatosis results in the formation of nodules, usually with indistinct borders. Consolidation of lung lobs and a hilar lymphadenopathy may also be seen.
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==Bronchoscopy==
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Bronchoscopy may reveal increased amounts of mucous in the airways which may have a greenish appearannce
    
[[Category:Allergic Respiratory Diseases]][[Category:To_Do_-_KatieB]]
 
[[Category:Allergic Respiratory Diseases]][[Category:To_Do_-_KatieB]]
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