Changes

#* C4b binds to the antigen.

#* C4b binds to the antigen.

# C4b then binds C2.

# C4b then binds C2.

#* C2 is digested by C1 esterase to form C2a and C2bThe C4b2b complex is an enzyme (C ) that is capable of efficient digestion of C3 into C3a and C3b. The production of C3b can now be amplified by the same mechanism as the alternative pathway. The binding of one C1q molecule produces one C1 esterase molecule that then cause the binding of many hundreds of C molecules. The C3b molecule that is produced by the action of this enzyme can also bind to it, forming the complex enzyme C , which is the second enzyme capable of activating C5 and initiating the MAC. Like the alternative pathway, the major effects of classical pathway activation are to produce iC3b and hence it promotes phagocytosis and initiates inflammation.

#* C2 is digested by C1 esterase to form C2a and C2b.

#** C4b and C2b complex to form the enzyme C2b¯4b.

# C2b¯4b digests of C3 into C3a and C3b.  

#* The production of C3b can now be amplified by the same mechanism as the alternative pathway.  

* The binding of one C1q molecule produces one C1 esterase molecule that then cause the binding of many hundreds of C molecules. The C3b molecule that is produced by the action of this enzyme can also bind to it, forming the complex enzyme C , which is the second enzyme capable of activating C5 and initiating the MAC. Like the alternative pathway, the major effects of classical pathway activation are to produce iC3b and hence it promotes phagocytosis and initiates inflammation.

. All the Ca fragments (C2a, C3a, C4a, C5a) are chemotactic for neutrophils and are potent inducers of acute inflammation (they are termed the anaphylotoxins).  

. All the Ca fragments (C2a, C3a, C4a, C5a) are chemotactic for neutrophils and are potent inducers of acute inflammation (they are termed the anaphylotoxins).  

*# '''The binding of soluble lectins to pathogens'''.  

*# '''The binding of soluble lectins to pathogens'''.