Changes

*The increase in blood supply also causes formation of oedema within the follicles due to increased hydrostatic pressure within the ovarian capillaries. This oedema causes an increase in intra-follicular pressure.

*The increase in blood supply also causes formation of oedema within the follicles due to increased hydrostatic pressure within the ovarian capillaries. This oedema causes an increase in intra-follicular pressure.

'''Progesterone Synthesis'''

'''Progesterone Synthesis'''

*LH causes a shift from oestrogen to progesterone production by follicular Granulosa cells. This local increase in progesterone stimulates Theca cells to produce the enzyme Collagenase, which breakdown the collagen within the [[Female Reproductive Tract -The Ovary - Anatomy & Physiology|Tunica Albuginea]] weakening the follicle wall.

*LH causes a shift from oestrogen to progesterone production by follicular Granulosa cells. This local increase in progesterone stimulates Theca cells to produce the enzyme Collagenase, which breakdown the collagen within the [[Ovary - Anatomy & Physiology|Tunica Albuginea]] weakening the follicle wall.

'''Increase in Prostaglandin F2a'''

'''Increase in Prostaglandin F2a'''

*PGF2a stimulates Granulosa cells to release lysosomes containing digestive enzymes. These enzymes contribute to the degradation of the Tunica Albuginea collagen and so the weakening of the follicle wall.

*PGF2a stimulates Granulosa cells to release lysosomes containing digestive enzymes. These enzymes contribute to the degradation of the Tunica Albuginea collagen and so the weakening of the follicle wall.