Difference between revisions of "Adrenogenital Syndrome"
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== Aetiology == | == Aetiology == | ||
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* Genotype is XX as should be female | * Genotype is XX as should be female | ||
* Ovaries develop normally | * Ovaries develop normally | ||
| − | * Foetal [[ | + | * Foetal [[Adrenal_Glands_- Anatomy & Physiology|Adrenal Gland]] is hyperactive and secretes large quantities of Adrenal Androgens, due to a '''21 hydroxylase mutation'''. |
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* Mullarian Ducts persist due to the absence of testes, hence absence of Sertoli cell MIH secretion. This allows formation of '''female internal genitalia'''. | * Mullarian Ducts persist due to the absence of testes, hence absence of Sertoli cell MIH secretion. This allows formation of '''female internal genitalia'''. | ||
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| + | == Morphology == | ||
| + | * Appears male with a '''micropenis and scrotum''' | ||
| + | * Both male and female internal genitalia | ||
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| − | + | [[Category:Reproductive Disorders]] | |
| − | + | [[Category:Reproductive Diseases - Dog]][[Category:Reproductive Diseases - Cat]] | |
Latest revision as of 14:25, 23 December 2010
Aetiology
- Genotype is XX as should be female
- Ovaries develop normally
- Foetal Adrenal Gland is hyperactive and secretes large quantities of Adrenal Androgens, due to a 21 hydroxylase mutation.
Consequence
- Wolffian Ducts persist due to the presence of Androgens, thus allowing development of male internal and external genitalia.
- Mullarian Ducts persist due to the absence of testes, hence absence of Sertoli cell MIH secretion. This allows formation of female internal genitalia.
Morphology
- Appears male with a micropenis and scrotum
- Both male and female internal genitalia