Difference between revisions of "Bovine Leukocyte Adhesion Deficiency"

Revision as of 19:01, 10 January 2011

(BLAD)

Occurs in Holstein cattle
Missence mutation of -Asp-128-Gly in CD18 molecule
Recurrent infection, e.g. pneumonia

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Bovine leukocyte adhesion deficiency syndrome (BLAD): a recessive disorder in Holstein Friesian cattle - a review. Vijay Kumar; Ashwani Sharma; Agricultural Research Communication Centre, Karnal, India, Agricultural Reviews, 2009, 30, 4, pp 293-300, many ref. - Full Text Article

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-{{OpenPagesTop}}
+(BLAD)
-Also known as '''''BLAD'''''
+*Occurs in Holstein cattle
+*Missence mutation of -Asp-128-Gly in CD18 molecule
+*Recurrent infection, e.g. pneumonia
-== Introduction ==
+==Literature Search==
+[[File:CABI logo.jpg|left|90px]]
-This is an autosomal recessive disorder seen in Holstein Cattle mainly in the USA and is caused by a missence mutation of -Asp-128-Gly in CD18 molecule. It is characterised by premature death and chronic bacterial infections such as recurrent [[:Category:Pneumonia|pneumonia]]. All animals with this mutation can be traced to sire many years ago. In the USA, around 15% of cattle have this mutation.
-Affected calves will appear normal at birth but then become clinically ill within the first few weeks. Life expectancy is generally not more than one year old.
+Use these links to find recent scientific publications via CAB Abstracts (log in required unless accessing from a subscribing organisation).
+<br><br><br>
+[http://www.cabi.org/cabdirect/FullTextPDF/2010/20103049446.pdf ''' Bovine leukocyte adhesion deficiency syndrome (BLAD): a recessive disorder in Holstein Friesian cattle - a review.''' Vijay Kumar; Ashwani Sharma; Agricultural Research Communication Centre, Karnal, India, Agricultural Reviews, 2009, 30, 4, pp 293-300, many ref. - '''Full Text Article''']
-== Clinical Signs ==
-Chronic recurrent infections such as pneumonia, diarrhoea, dermatitis, gingivitis or vasculitis. The infection will always reappear, even following antibiotic doses usually high enough to cure the infection.
+[[Category:Primary Innate Immunity Deficiencies]]
+[[Category:Lymphoreticular and Haematopoietic Diseases - Cattle]]
-== Diagnosis ==
+[[Category:To Do - Blood]][[Category:To Do - Clinical]]
-There are tests available in the US to diagnose heterozygous carriers and homozygous calves.
-== Control ==
-Test the herd and eliminate carrier animals.
-{{Learning
-|full text = [http://www.cabi.org/cabdirect/FullTextPDF/2010/20103049446.pdf '''Bovine leukocyte adhesion deficiency syndrome (BLAD): a recessive disorder in Holstein Friesian cattle - a review.''' Vijay Kumar; Ashwani Sharma; Agricultural Research Communication Centre, Karnal, India, Agricultural Reviews, 2009, 30, 4, pp 293-300, many ref.]
-}}
-== References ==
-Andrews, A.H, Blowey, R.W, Boyd, H and Eddy, R.G. (2004) Bovine Medicine (Second edition), Blackwell Publishing
-Radostits, O.M, Arundel, J.H, and Gay, C.C. (2000) Veterinary Medicine: a textbook of the diseases of cattle, sheep, pigs, goats and horses Elsevier Health Sciences
-{{review}}
-{{OpenPages}}
-[[Category:Primary_Innate_Immunity_Deficiencies]] [[Category:Lymphoreticular_and_Haematopoietic_Diseases_-_Cattle]] [[Category:Expert_Review - Farm Animal]]

Difference between revisions of "Bovine Leukocyte Adhesion Deficiency"

Revision as of 19:01, 10 January 2011

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