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{{unfinished}}
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{{unfinished}}  
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====Hosts====
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==== Hosts ====
*Sheep
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*Grouse
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*Sheep  
*Hares
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*Grouse  
*Deer elk
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*Hares  
*Small rodents
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*Deer elk  
*Ticks (eg. ''Ixodes ricinus'')
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*Small rodents  
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*Ticks (eg. ''Ixodes ricinus'')  
 
*Man
 
*Man
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====Pathogenesis====
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==== Pathogenesis ====
*First phase:
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**Pyrexia with virus in '''macrophages'''
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*First phase:  
**Recovery
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**Pyrexia with virus in '''macrophages'''  
*Second phase:
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**Recovery  
**Second replication in '''Purkinje cells''' of the cerebellum and '''motor nuclei''' of the brain stem
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*Second phase:  
**Trembling, torticollis, and irregular gait
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**Second replication in '''Purkinje cells''' of the cerebellum and '''motor nuclei''' of the brain stem  
**In grouse: starvation
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**Trembling, torticollis, and irregular gait  
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**In grouse: starvation  
 
**In man: flu-like symptoms can be followed by coma, but recovery normal
 
**In man: flu-like symptoms can be followed by coma, but recovery normal
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====Epidemiology====
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==== Epidemiology ====
*Reservoir host: '''Ticks (''Ixodes ricinus'')'''
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**Passed to host by '''saliva'''
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*Reservoir host: '''Ticks (''Ixodes ricinus'')'''  
**Virus can be spread '''between ticks''' when co-feeding on small rodents
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**Passed to host by '''saliva'''  
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**Virus can be spread '''between ticks''' when co-feeding on small rodents  
 
*Spread mirrors seasonal tick activity
 
*Spread mirrors seasonal tick activity
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====Diagnosis====
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==== Diagnosis ====
*Clinical signs
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*Clinical signs  
 
*PM: virus isolation and histopathology of brain tissue
 
*PM: virus isolation and histopathology of brain tissue
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====Control====
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==== Control ====
*Sheep dipping in '''acaracides''' (vector control)
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*'''Inactivated vaccines''' in late pregnancy can '''boost maternal antibody'''
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*Sheep dipping in '''acaracides''' (vector control)  
**Lambs inoculated >4 months of age
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*'''Inactivated vaccines''' in late pregnancy can '''boost maternal antibody'''  
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**Lambs inoculated >4 months of age  
 
*Human vaccination where at risk
 
*Human vaccination where at risk
[[Category:Flaviviruses]][[Category:Sheep Viruses]][[Category:Poultry]][[Category:Zoonoses]][[Category:Rodents]]
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[[Category:To_Do_-_Clinical/Viruses]]
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[[Category:Flaviviruses]] [[Category:Sheep_Viruses]] [[Category:Avian Viruses]] [[Category:Zoonoses]] [[Category:Rodents]] [[Category:To_Do_-_Clinical/Viruses]] [[Category:Neurological_Diseases_-_Sheep]]
[[Category:Neurological Diseases - Sheep]]
 
Author, Donkey, Bureaucrats, Administrators
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