VetPrep Q6

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A 10-year old male castrated cat presents for inappetence and depression of one week in duration. On physical exam, the cat appears to be in good condition (BCS 4/9). T:101.2F, HR:180, RR:30. You note that the sclera appear slightly icteric. Remainder of the physical exam is unremarkable.

You perform bloodwork which shows:

Complete blood count:

Hematocrit - 27%

White blood cell count- 16,678/ul

Neutrophils- 7,278/ul

Lymphocytes- 8,300/ul

Monocytes- 500/ul

Eosinophils- 600/ul

Platelets- 264,000/ul

Serum chemistry shows:

Creatinine- 1.4 mg/dl

Blood urea nitrogen (BUN)- 29 mg/dl

Glucose- 110 mg/dl

Albumin= 2.4 g/dl

Globulin= 6.6 g/dl

ALP- 476 IU/L

ALT- 349 IU/L

GGT- 21 IU/L

Total bilirubin- 2.6 mg/dl

You take thoracic radiographs which are unremarkable.

You perform an abdominal ultrasound and find that the liver appears enlarged with normal echogenicity. The gall bladder is mildly distended, no choleliths are seen. You perform an aspirate of the liver and obtain a bile sample for culture and sensitivity which shows growth of aerobes and anaerobes that are sensitive to ampicillin, trimethoprim-sulfa, amoxicillin, choloramphenicol, and tetracycline.

6

You diagnose the cat with cholangiohepatitis and institute therapy. Which of the following antibiotic plans is most appropriate? Amoxicillin for 3-4 weeks Chloramphenicol for 6 months Trimethoprim-sulfa for 2-4 months Tetracycline for 1-2 weeks Ampicillin for 2-3 months Please select an option Incorrect. Cats with cholangiohepatitis should be treated with antibiotics for at least 2 months. The antibiotic chosen should also be excreted unchanged in the bile. All of the antibiotics listed undergo biliary excretion unchanged except for trimethoprim-sulfa which is primarily excreted through the kidneys and undergoes hepatic metabolism. Therefore, the best answer is ampicillin for 2-3 months. WikiVet Article: Cholangiohepatitis Incorrect. Cats with cholangiohepatitis should be treated with antibiotics for at least 2 months. The antibiotic chosen should also be excreted unchanged in the bile. All of the antibiotics listed undergo biliary excretion unchanged except for trimethoprim-sulfa which is primarily excreted through the kidneys and undergoes hepatic metabolism. Therefore, the best answer is ampicillin for 2-3 months. WikiVet Article: Cholangiohepatitis Incorrect. Cats with cholangiohepatitis should be treated with antibiotics for at least 2 months. The antibiotic chosen should also be excreted unchanged in the bile. All of the antibiotics listed undergo biliary excretion unchanged except for trimethoprim-sulfa which is primarily excreted through the kidneys and undergoes hepatic metabolism. Therefore, the best answer is ampicillin for 2-3 months. WikiVet Article: Cholangiohepatitis Incorrect. Cats with cholangiohepatitis should be treated with antibiotics for at least 2 months. The antibiotic chosen should also be excreted unchanged in the bile. All of the antibiotics listed undergo biliary excretion unchanged except for trimethoprim-sulfa which is primarily excreted through the kidneys and undergoes hepatic metabolism. Therefore, the best answer is ampicillin for 2-3 months. WikiVet Article: Cholangiohepatitis Correct! Cats with cholangiohepatitis should be treated with antibiotics for at least 2 months. The antibiotic chosen should also be excreted unchanged in the bile. All of the antibiotics listed undergo biliary excretion unchanged except for trimethoprim-sulfa which is primarily excreted through the kidneys and undergoes hepatic metabolism. Therefore, the best answer is ampicillin for 2-3 months. WikiVet Article: Cholangiohepatitis