Feline Herpesvirus 1: Difference between revisions

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rarely causes skin infections

Pathogenesis

Upper respiratory tract infection: Feline Viral Rhinotracheitis
- Viruses and bacteria are involved in the complex
- The most frequent aetiologic agent is FHV-1, and less frequently feline calicivirus and/or Chlamydophila psittaci
- All three agents infect URT respiratory epithelium, although FHV-1 has the highest affinity for this epithelium
  - Feline calicivirus more frequently infects the oral mucosa -> ulcerative stomatitis
  - C.psittaci more frequently infects the conjunctival epithelium -> chronic conjunctivitis
- Infection of the respiratory epithelium by FHV-1 results in a typical neutrophilic rhinitis with intraepitheial intranuclear eosinophilic inclusion bodies, with expected clinical signs
- Resolution of clinical signs usually occurs by 7-14 days
- FHV-1 remains latent in the trigeminal ganglion, and can reactivate at times of stress: Can infect the cornea -> ulcerative keratitis
- Occasional mortality in kitten or immunocompromised animals usually associated with secondary bacterial infection
Erosions can affect the bronchi, resulting in interstitial pneumonia
Most common cause of keratitis and corneal ulcers in cat and gummy eyes in kittens
- Rupture is a particular risk

Epidemiology

Widespread
Serious infection
Latent infection can be reactivated on boarding

Diagnosis

Nasal swabs on first week of infection can be cultured for virus isolation

Treatment

For keratitis with corneal ulcers:

Subcut omega interferon
Topical trifluorothymidine (thymidine analogue) on eyes

Control

Killed and live vaccines are available
- Live vaccines have provoked symptoms in immunosuppressed kittens and are no longer used in the UK

Feline viral rhinotracheitis

Caused by a herpesvirus
Tends to be more rhinitis than tracheitis, may extend to sinusitis
Feline herpesvirus -1
- One of the causes of Feline viral rhinotracheitis
  - Viruses and bacteria are involved in the complex. The most frequent aetiologic agent is FHV-1, and less frequently feline calicivirus and/or Chlamydophila psittaci (NB: previously called Chlamydia psittaci var felis)
All three agents infect URT respiratory epithelium, although FHV-1 has the highest affinity for this epithelium
Feline calicivirus more frequently infects the oral mucosa -> ulcerative stomatitis
C.psittaci more frequently infects the conjunctival epithelium -> chronic conjunctivitis
Infection of the respiratory epithelium by FHV-1 results in a typical neutrophilic rhinitis with intraepitheial intranuclear eosinophilic inclusion bodies
Uncomplicated cases resolve in 2-3 weeks
FHV-1 remains latent in the trigeminal ganglion, and can reactivate at times of stress
Can infect the cornea -> ulcerative keratitis
Mortality may be high in young kittens, debilitated and immune-suppressed animals, usually associated with secondary bacterial infection.

Links

ABCD information

@@ Line 1: / Line 1: @@
-{{OpenPagesTop}}
+{{unfinished}}
-== Introduction  ==
-Feline Herpes virus ('''FHV-1''') causes an upper respiratory tract infection: '''Feline Viral Rhinotracheitis'''.
+rarely causes skin infections
+====Pathogenesis====
+*Upper respiratory tract infection: Feline Viral Rhinotracheitis
+**Viruses and bacteria are involved in the complex
+** The most frequent aetiologic agent is FHV-1, and less frequently feline calicivirus and/or ''[[Chlamydophila psittaci]]''
+**All three agents infect URT respiratory epithelium, although FHV-1 has the highest affinity for this epithelium
+***Feline calicivirus more frequently infects the oral mucosa -> ulcerative stomatitis
+***C.psittaci more frequently infects the conjunctival epithelium -> chronic conjunctivitis
+**Infection of the respiratory epithelium by FHV-1 results in a typical neutrophilic rhinitis with intraepitheial intranuclear eosinophilic inclusion bodies, with expected clinical signs
+**Resolution of clinical signs usually occurs by 7-14 days
+**FHV-1 remains '''latent''' in the trigeminal ganglion, and can reactivate at times of stress: Can infect the cornea -> ulcerative keratitis
+**Occasional mortality in kitten or immunocompromised animals usually associated with secondary bacterial infection
+*Erosions can affect the bronchi, resulting in '''interstitial pneumonia'''
+*Most common cause of '''keratitis''' and '''corneal ulcers''' in cat and '''gummy eyes''' in kittens
+**Rupture is a particular risk
-Viruses and bacteria are involved in the complex, with the most frequent aetiologic agent being FHV-1, and less frequently [[Feline Calicivirus|feline calicivirus]] and/or ''[[Chlamydophila psittaci]]''. All three agents infect URT respiratory epithelium, although FHV-1 has the highest affinity for this epithelium. Feline calicivirus more frequently infects the oral mucosa -> ulcerative stomatitis and ''C. felis'' more frequently infects the conjunctival epithelium -> chronic conjunctivitis. All three together will result in the disease complex 'cat flu'.
+====Epidemiology====
+*Widespread
+*Serious infection
+*Latent infection can be reactivated on boarding
-Infection of the respiratory epithelium by FHV-1 results in a typical neutrophilic rhinitis with intraepithelial intranuclear eosinophilic inclusion bodies, with expected clinical signs. Resolution of these clinical signs usually occurs by 7-14 days, however, FHV-1 remains '''latent''' in the trigeminal ganglion, and can reactivate at times of stress. It can infect the cornea - ulcerative keratitis. FHV- 1 is the most common cause of keratitis and corneal ulcers in cats and gummy eyes in kittens.
+====Diagnosis====
+*'''Nasal swabs''' on first week of infection can be cultured for virus isolation
-Occasional mortality can occur in the kitten or immunocompromised animals usually associated with secondary bacterial infections.
+====Treatment====
+For keratitis with corneal ulcers:
+*Subcut omega interferon
+*Topical trifluorothymidine (thymidine analogue) on eyes
-The virus is widespread and common. It can cause serious infections as well as latent infections which can be reactivated on boarding or at other periods of stress.
+====Control====
+*Killed and live '''vaccines''' are available
+**Live vaccines have provoked symptoms in immunosuppressed kittens and are no longer used in the UK
-== Clinical Signs  ==
+===Feline viral rhinotracheitis===
-Upper respiratory tract signs such as [[rhinitis]], [[tracheitis]] and [[sinusitis]] as well as keratitis and [[Corneal Ulceration - Dogs and Cats|corneal ulcers]]. The corneal ulcers intially have a '''dendritic''' appearence, which is considered pathognomic. In combination with other agents, will cause 'cat flu' which will include sneezing, coughing, gummy eyes, nasal discharge, dyspnoea and conjunctivitis.
+*Caused by a [[Herpesviridae|herpesvirus]]
+*Tends to be more [[Rhinitis#Infectious causes of rhinitis|rhinitis]] than [[Trachea Inflammatory - Pathology#Infectious causes of tracheitis|tracheitis]], may extend to [[Paranasal Sinuses Inflammatory - Pathology#Infectious causes of sinusitis|sinusitis]]
+*Feline herpesvirus -1
+**One of the causes of Feline viral rhinotracheitis
+***Viruses and bacteria are involved in the complex. The most frequent aetiologic agent is [[Herpesviridae|FHV-1]], and less frequently [[Caliciviridae|feline calicivirus]] and/or ''[[Chlamydophila psittaci]]'' (NB: previously called ''Chlamydia psittaci'' var felis)
+*All three agents infect URT respiratory epithelium, although FHV-1 has the highest affinity for this epithelium
+*Feline calicivirus more frequently infects the oral mucosa -> ulcerative stomatitis
+*''C.psittaci'' more frequently infects the conjunctival epithelium -> chronic conjunctivitis
+*Infection of the respiratory epithelium by FHV-1 results in a typical neutrophilic rhinitis with intraepitheial intranuclear eosinophilic [[Cellular Inclusions|inclusion bodies]]
+*Uncomplicated cases resolve in 2-3 weeks
+*FHV-1 remains latent in the trigeminal ganglion, and can reactivate at times of stress
+*Can infect the cornea -> ulcerative keratitis
+*Mortality may be high in young kittens, debilitated and immune-suppressed animals, usually associated with secondary bacterial infection.
-== Diagnosis  ==
+==Links==
-Clinical signs and history are usually used as a presumptive diagnosis prior to definitive diagnosis via laboratory tests.
+[http://www.abcd-vets.org/guidelines/feline_herpesvirus/index.asp ABCD information]
-'''Nasal swabs''' on first week of infection can be cultured for virus isolation, plus a swab of the eye.
-== Treatment  ==
+[[Category:Herpesviridae]][[Category:To_Do_-_Clinical/Viruses]][[Category:Cat Viruses]][[Category:Respiratory Diseases - Cat]]
+[[Category:Respiratory_Viral_Infections]]
-For keratitis with corneal ulcers treat with subcutaneous omega interferon and give topical trifluorothymidine (thymidine analogue) on eyes.
-== Control  ==
-Killed and live '''[[vaccines]]''' are available. Live vaccines have provoked symptoms in immunosuppressed kittens and are no longer used in the UK.
-== References  ==
-Bridger, J and Ruseel, P, (2007) Virology Study Guide, Royal Veterinary College
-Ettinger, S.J. and Feldman, E. C. (2000) Textbook of Veterinary Internal Medicine Diseases of the Dog and Cat Volume 2 (Fifth Edition), W.B. Saunders Company
-Ettinger, S.J, Feldman, E.C. (2005) Textbook of Veterinary Internal Medicine (6th edition, volume 2), W.B. Saunders Company
-Merck & Co (2008) The Merck Veterinary Manual (Eighth Edition), Merial
-{{Learning
-|powerpoints = [[E-Lecture:Feline Herpesvirus-1]]
-|Vetstream = [https://www.vetstream.com/felis/Content/Disease/dis60212 Feline herpesvirus disease]
-}}
-{{review}}
-{{OpenPages}}
-[[Category:Herpesviridae]] [[Category:Expert_Review - Small Animal]] [[Category:Cat_Viruses]] [[Category:Respiratory_Diseases_-_Cat]] [[Category:Respiratory_Viral_Infections]]
-[[Category:Hepatitis, Viral]]